ID | 32306 |
JaLCDOI | |
フルテキストURL | |
著者 |
Hashimoto, Yasuhiko
Okayama University
Gomita, Yutaka
Okayama University
|
抄録 | The influences of emotional changes induced by being exposed to a new environment on the pharmacokinetics of plasma drug concentration were studied in male Wistar rats. Transfer from a familiar home cage to a new home cage was considered to induce psychological (non-physical) emotional changes. First, nicorandil and zonisamide, drugs that act on the peripheral system and central nervous systems, were used, respectively. Immediately after oral administration of nicorandil (10 mg/kg) or zonisamide (50 mg/kg), the animals were transferred to new home cages. Plasma nicorandil and zonisamide concentrations were determined by high-performance liquid chromatography at 1 and 4 h after administration. Plasma nicorandil concentration in the group transferred to new home cages was significantly decreased relative to levels in the non-transferred control group. However, zonisamide concentrations were unchanged. These findings suggest that the pharmacokinetics of nicorandil, but not those of zonisamide, tend to be influenced by non-physically induced emotional changes. |
キーワード | psychologically induced emotional changes
drug plasma concentration
nicorandil
zonisamide
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 2000-02
|
巻 | 54巻
|
号 | 1号
|
出版者 | Okayama University Medical School
|
開始ページ | 45
|
終了ページ | 48
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
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PubMed ID | |
Web of Science KeyUT |