このエントリーをはてなブックマークに追加
ID 31328
JaLCDOI
フルテキストURL
著者
Suemaru, Katsuya Okayama University
Kawasaki, Hiromu Okayama University Kaken ID publons
Yasuhara, Kanako Okayama Univeristy
Yao, Kazuhisa Okayama University
Furuno, Katusushi Okayama University
Kawakami, Yasuhiro Okayama University
Araki, Hiroaki Okayama University
Gomita, Yutaka Okayama University
Oka, Eiji Okayama University
抄録

Steady-state serum concentrations of carbamazepine (CBZ) and valproic acid (VPA) were investigated in normal weight (body mass index; BMI 20 to 25), lean (smaller than 20 BMI) and moderately obese subjects (greater than 25 BMI) who received either 400 mg/day of CBZ or 800 mg/day of VPA. The CBZ serum concentration in lean subjects was significantly higher than that in normal weight subjects. However, no significant differences in VPA serum concentration were found between the three groups. The CBZ serum concentration decreased with increases in total body weight, and the VPA serum concentration decreased with increases in ideal body weight. However, both serum concentrations were not correlated with BMI. These results suggest that VPA doses should be calculated using ideal body weight and that degree of obesity may affect CBZ serum concentration rather than VPA serum concentration.

キーワード
carbamazepine
valproic acid
serum concentration
obesity
lean
Amo Type
Article
出版物タイトル
Acta Medica Okayama
発行日
1998-06
52巻
3号
出版者
Okayama University Medical School
開始ページ
139
終了ページ
142
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
英語
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT