ID | 31328 |
JaLCDOI | |
フルテキストURL | |
著者 |
Suemaru, Katsuya
Okayama University
Yasuhara, Kanako
Okayama Univeristy
Yao, Kazuhisa
Okayama University
Furuno, Katusushi
Okayama University
Kawakami, Yasuhiro
Okayama University
Araki, Hiroaki
Okayama University
Gomita, Yutaka
Okayama University
Oka, Eiji
Okayama University
|
抄録 | Steady-state serum concentrations of carbamazepine (CBZ) and valproic acid (VPA) were investigated in normal weight (body mass index; BMI 20 to 25), lean (smaller than 20 BMI) and moderately obese subjects (greater than 25 BMI) who received either 400 mg/day of CBZ or 800 mg/day of VPA. The CBZ serum concentration in lean subjects was significantly higher than that in normal weight subjects. However, no significant differences in VPA serum concentration were found between the three groups. The CBZ serum concentration decreased with increases in total body weight, and the VPA serum concentration decreased with increases in ideal body weight. However, both serum concentrations were not correlated with BMI. These results suggest that VPA doses should be calculated using ideal body weight and that degree of obesity may affect CBZ serum concentration rather than VPA serum concentration. |
キーワード | carbamazepine
valproic acid
serum concentration
obesity
lean
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1998-06
|
巻 | 52巻
|
号 | 3号
|
出版者 | Okayama University Medical School
|
開始ページ | 139
|
終了ページ | 142
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |