ID | 57807 |
フルテキストURL | |
著者 |
Sugimoto, Seiichiro
Department of General Thoracic Surgery, Okayama University Hospital
ORCID
Kaken ID
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Yamamoto, Haruchika
Department of General Thoracic Surgery, Okayama University Hospital
Kurosaki, Takeshi
Department of Organ Transplant Center, Okayama University Hospital
Kaken ID
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Otani, Shinji
Department of Organ Transplant Center, Okayama University Hospital
Kaken ID
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Okazaki, Mikio
Department of General Thoracic Surgery, Okayama University Hospital
Yamane, Masaomi
Department of General Thoracic Surgery, Okayama University Hospital
Kaken ID
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Toyooka, Shinichi
Department of General Thoracic Surgery, Okayama University Hospital
ORCID
Kaken ID
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抄録 | PURPOSE:
The differences in chronic lung allograft dysfunction (CLAD) between living-donor lobar lung transplantation (LDLLT) and cadaveric lung transplantation (CLT) remain unclear. We conducted this study to compare the impact of CLAD on the outcomes after LDLLT vs. CLT. METHODS: We conducted a retrospective review of the data of 97 recipients of bilateral lung transplantation, including 51 recipients of LDLLT and 46 recipients of CLT. RESULTS: The CLAD-free survival and overall survival after LDLLT were similar to those after CLT. CLAD and restrictive allograft syndrome (RAS), but not bronchiolitis obliterans syndrome (BOS), developed significantly later after LDLLT than after CLT (p = 0.015 and p = 0.035). Consequently, patients with CLAD and RAS, but not those with BOS, after LDLLT had a significantly better overall survival than those after CLT (p = 0.037 and p = 0.0006). Furthermore, after the diagnosis of CLAD, the survival of patients with RAS after LDLLT tended to be better than that after CLT (p = 0.083). CONCLUSION: CLAD, especially RAS, appears to develop later after LDLLT than after CLT and seems to have a lower impact on the overall survival after LDLLT than that after CLT. |
キーワード | Bronchiolitis obliterans syndrome
Chronic lung allograft dysfunction
Living-donor
Lung transplantation
Rejection
Restrictive allograft syndrome
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発行日 | 2019-02-21
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出版物タイトル |
Surgery Today
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巻 | 49巻
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号 | 8号
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出版者 | Springer
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開始ページ | 686
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終了ページ | 693
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ISSN | 0941-1291
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NCID | AA10824685
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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論文のバージョン | author
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PubMed ID | |
DOI | |
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関連URL | isVersionOf https://doi.org/10.1007/s00595-019-01782-0
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ライセンス | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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Citation | Sugimoto, S., Yamamoto, H., Kurosaki, T. et al. Impact of chronic lung allograft dysfunction, especially restrictive allograft syndrome, on the survival after living-donor lobar lung transplantation compared with cadaveric lung transplantation in adults: a single-center experience. Surg Today 49, 686–693 (2019) doi:10.1007/s00595-019-01782-0
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