ID | 57898 |
フルテキストURL | |
著者 |
Ozuru, Ryo
Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University
Wakao, Shohei
Department of Stem Cell Biology and Histology, Graduate School of Medicine, Tohoku University
Tsuji, Takahiro
Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University
Ohara, Naoya
Department of Oral Microbiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
publons
researchmap
Matsuba, Takashi
Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University
Amuran, Muhammad Y.
Department of Neurology, Hasanuddin University Faculty of Medicine
Isobe, Junko
Department of Bacteriology, Toyama Institute of Health
Iino, Morio
Division of Legal Medicine, Department of Social Medicine, Faculty of Medicine, Tottori University
Nishida, Naoki
Department of Legal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
Matsumoto, Sari
Department of Forensic Medicine, The Jikei University School of Medicine
Iwadate, Kimiharu
Department of Forensic Medicine, The Jikei University School of Medicine
Konishi, Noriko
Department of Food Microbiology, Tokyo Metropolitan Institute of Public
Yasuda, Kaori
Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
Tashiro, Kosuke
Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University
Hida, Misato
Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University
Yadoiwa, Arisato
Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University
Kato, Shinsuke
Division of Neuropathology, Department of Brain and Neuroscience, Faculty of Medicine, School of Medicine, Tottori University Faculty of Medicine
Yamashita, Eijiro
Division of Clinical Radiology, Tottori University Hospital
Matsumoto, Sohkichi
Department of Bacteriology, Niigata University School of Medicine
Kurozawa, Yoichi
Division of Health Administration and Promotion, Department of Social Medicine, Faculty of Medicine, Tottori University
Dezawa, Mari
Department of Stem Cell Biology and Histology, Graduate School of Medicine, Tohoku University
Fujii, Jun
Division of Bacteriology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori University
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抄録 | Shiga toxin-producing Escherichia coli (STEC) causes hemorrhagic colitis, hemolytic uremic syndrome, and acute encephalopathies that may lead to sudden death or severe neurologic sequelae. Current treatments, including immunoglobulin G (IgG) immunoadsorption, plasma exchange, steroid pulse therapy, and the monoclonal antibody eculizumab, have limited effects against the severe neurologic sequelae. Multilineage-differentiating stress-enduring (Muse) cells are endogenous reparative non-tumorigenic stem cells that naturally reside in the body and are currently under clinical trials for regenerative medicine. When administered intravenously, Musecells accumulate to the damaged tissue, where they exert anti-inflammatory, anti-apoptotic, anti-fibrotic, and immunomodulatory effects, and replace damaged cells by differentiating into tissue-constituent cells. Here, severely immunocompromised non-obese diabetic/severe combined immunodeficiency (NOD-SCID) mice orally inoculated with 9 × 109 colony-forming units of STEC O111 and treated 48 h later with intravenous injection of 5 × 104 Muse cells exhibited 100% survival and no severe after-effects of infection. Suppression of granulocyte-colony-stimulating factor (G-CSF) by RNAi abolished the beneficial effects of Muse cells, leading to a 40% death and significant body weight loss, suggesting the involvement of G-CSF in the beneficial effects of Muse cells in STEC-infected mice. Thus, intravenous administration of Muse cells could be a candidate therapeutic approach for preventing fatal encephalopathy after STEC infection.
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キーワード | Muse cells
Shiga toxin-producing Escherichia coli
acute encephalopathy
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発行日 | 2020-01-08
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出版物タイトル |
Molecular Therapy
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巻 | 28巻
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号 | 1号
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出版者 | Elsevier
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開始ページ | 100
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終了ページ | 118
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ISSN | 15250016
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NCID | AA11475060
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2019 The Author(s).
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1016/j.ymthe.2019.09.023
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ライセンス | http://creativecommons.org/licenses/by/4.0/
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Citation | Ryo Ozuru, Shohei Wakao, Takahiro Tsuji, Naoya Ohara, Takashi Matsuba, Muhammad Y. Amuran, Junko Isobe, Morio Iino, Naoki Nishida, Sari Matsumoto, Kimiharu Iwadate, Noriko Konishi, Kaori Yasuda, Kosuke Tashiro, Misato Hida, Arisato Yadoiwa, Shinsuke Kato, Eijiro Yamashita, Sohkichi Matsumoto, Yoichi Kurozawa, Mari Dezawa, Jun Fujii, Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice, Molecular Therapy, Volume 28, Issue 1, 2020, Pages 100-118, ISSN 1525-0016, https://doi.org/10.1016/j.ymthe.2019.09.023.
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オープンアクセス(出版社) |
OA
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オープンアーカイブ(出版社) |
非OpenArchive
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