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ID 62512
フルテキストURL
著者
Yamashita, Koichiro Graduate School of Natural Science and Technology, Okayama University
Mitsui, Mayu Graduate School of Natural Science and Technology, Okayama University
Matsuo, Toshihiko Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University ORCID Kaken ID publons researchmap
Uchida, Tetsuya Graduate School of Natural Science and Technology, Okayama University ORCID Kaken ID publons researchmap
抄録
Photoelectric dyes have stimulated retinal neurons by absorbing light and generating an electric potential. Therefore, a photoelectric dye was used to develop a retinal prosthesis to restore vision loss due to retinitis pigmentosa. The retinal prosthesis, referred to as a dye-coupled film, was prepared by chemically coupling the dyes to a polyethylene film surface through amide bonds. However, the coupled dyes decreased during an implantation test in a monkey eye. This study clarifies the degradation mechanism of the dye-coupled film. Since the dyes were selectively coupled to the film surface, it is difficult to detect the eliminated dyes in a solution. Therefore, a model compound that mimicked the chemical structure of the dye-coupled film by converting the carboxylic acid of dye to the amide bond is used. It was found that the elimination of the side chain, including the amide bond, occurred before the degradation of the conjugated structure according to mass spectrometry of the model compound. The degradation mechanism of the dye-coupled film was predicted based on that of the model compound. It was concluded that chemical bonds between the dye and the film surface were preferentially decomposed, leading to the detachment of the dyes from the film surface.
キーワード
Degradation
Photoelectric dye
Benzothiazole
Mass spectrometry
Retinal prosthesis
備考
© 2021 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.matlet.2021.130978] .
発行日
2021-10-01
出版物タイトル
Materials Letters
307巻
出版者
Elsevier
開始ページ
130978
ISSN
0167577X
資料タイプ
学術雑誌論文
言語
英語
OAI-PMH Set
岡山大学
著作権者
© 2021 Elsevier B.V.
論文のバージョン
author
DOI
Web of Science KeyUT
関連URL
isVersionOf https://doi.org/10.1016/j.matlet.2021.130978
ライセンス
http://creativecommons.org/licenses/by-nc-nd/4.0/
助成機関名
Japan Society for the Promotion of Science
助成番号
JP19J13826