ID | 61502 |
フルテキストURL | |
著者 |
Matsuo, Naoaki
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Miyoshi, Toru
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
Kaken ID
publons
Takaishi, Atsushi
Department of Cardiovascular Medicine, Mitoyo General Hospital
Kishinoue, Takao
Department of Cardiovascular Medicine, Mitoyo General Hospital
Yasuhara, Kentaro
Department of Cardiovascular Medicine, Mitoyo General Hospital
Tanimoto, Masafumi
Department of Cardiovascular Medicine, Mitoyo General Hospital
Nakano, Yukari
Nakano Cardiovascular Clinic
Onishi, Nobuhiko
Department of Cardiovascular Medicine, Mitoyo General Hospital
Ueeda, Masayuki
Ueeda Cardiovascular Clinic
Ito, Hiroshi
Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
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抄録 | The clinical relevance of polyunsaturated fatty acids (PUFAs) in heart failure remains unclear. The aim of this study was to investigate the association between PUFA levels and the prognosis of patients with heart failure with preserved ejection fraction (HFpEF). This retrospective study included 140 hospitalized patients with acute decompensated HFpEF (median age 84.0 years, 42.9% men). The patients' nutritional status was assessed, using the geriatric nutritional risk index (GNRI), and their plasma levels of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), arachidonic acid (AA), and dihomo-gamma-linolenic acid (DGLA) were measured before discharge. The primary outcome was all-cause mortality. During a median follow-up of 23.3 months, the primary outcome occurred in 37 patients (26.4%). A Kaplan-Meier analysis showed that lower DHA and DGLA levels, but not EPA or AA levels, were significantly associated with an increase in all-cause death (log-rank; p < 0.001 and p = 0.040, respectively). A multivariate Cox regression analysis also revealed that DHA levels were significantly associated with the incidence of all-cause death (HR: 0.16, 95% CI: 0.06-0.44, p = 0.001), independent of the GNRI. Our results suggest that low plasma DHA levels may be a useful predictor of all-cause mortality and potential therapeutic target in patients with acute decompensated HFpEF.
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キーワード | heart failure with preserved ejection fraction
docosahexaenoic acid
geriatric nutritional risk index
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発行日 | 2021-01-26
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出版物タイトル |
Nutrients
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巻 | 13巻
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号 | 2号
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出版者 | MDPI
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開始ページ | 371
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ISSN | 2072-6643
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2021 by the authors.
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.3390/nu13020371
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ライセンス | http://creativecommons.org/licenses/by/4.0/
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