Identification of factors related to functional prognoses in craniopharyngiomas

Umeda, Tsuyoshi; Otani, Yoshihiro; Fujii, Kentaro; Ishida, Joji; Hirano, Shuichiro; Suruga, Yasuki; Kemmotsu, Naoya; Imoto, Ryoji; Kegoya, Yasuhito; Mizuta, Ryo; Inoue, Yohei; Hokama, Madoka; Makihara, Seiichiro; Hasegawa, Kosei; Inagaki, Kenichi; Otsuka, Fumio; Yasuhara, Takao; Tanaka, Shota

doi:10.1007/s11060-024-04925-7

Permalink : http://escholarship.lib.okayama-u.ac.jp/68324

ID	68324
フルテキストURL	fulltext.pdf 1010 KB
著者	Umeda, Tsuyoshi Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Otani, Yoshihiro Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Fujii, Kentaro Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Ishida, Joji Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Hirano, Shuichiro Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Suruga, Yasuki Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kemmotsu, Naoya Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Imoto, Ryoji Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kegoya, Yasuhito Mizuta, Ryo Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Inoue, Yohei Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Hokama, Madoka Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Makihara, Seiichiro Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Hasegawa, Kosei Department of Pediatrics, Okayama University Hospital ORCID Kaken ID publons researchmap Inagaki, Kenichi Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons Otsuka, Fumio Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap Yasuhara, Takao Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap Tanaka, Shota Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
抄録	Purpose Craniopharyngiomas are histologically benign tumors, but their proximity to vital neurovascular structures can significantly deteriorate functional prognoses and severely restrict patients’ social interaction and activity. We retrospectively identified risk factors related to the functional prognoses in patients with craniopharyngioma treated at our center. Methods A retrospective analysis was conducted on 40 patients who underwent surgery for craniopharyngioma and follow-up at our institution between 2003 and 2022. Functional prognoses were evaluated in terms of obesity (body mass index [BMI] ≥ 25 for adults, BMI-Z ≥ 1.65 for children), visual function, endocrine function, and social participation. We investigated whether patient characteristics, tumor size, tumor location, hypothalamic involvement, surgical hypothalamic damage, extent of resection, and recurrence rate correlated with these functional prognostic factors. Results The median age at diagnosis was 28.0 years, with a median follow-up of 80.5 months. Postoperative obesity was present in 22 patients, and those with postoperative obesity had a significantly higher preoperative BMI or BMI-Z (preoperative BMI for adults: p = 0.074; preoperative BMI-Z for children: p = 0.020) and were significantly correlated with preoperative hypothalamic involvement grade 2 (p = 0.012) and surgical hypothalamic damage grade II (p = 0.0001). Deterioration in social participation was significantly associated with a larger tumor size (p = 0.023) and tumor recurrence (p = 0.0047). Conclusions Patients with higher preoperative BMI or BMI-Z and hypothalamic involvement have a greater risk of postoperative obesity, and larger tumor size and recurrence can significantly deteriorate the rate of patients’ social participation.
キーワード	Craniopharyngioma Functional prognosis Obesity Tumor size Social participation Hypothalamic involvement
備考	The version of record of this article, first published in Journal of Neuro-Oncology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s11060-024-04925-7
発行日	2025-01-22
出版物タイトル	Journal of Neuro-Oncology
出版者	Springer Science and Business Media LLC
ISSN	0167-594X
NCID	AA10633712
資料タイプ	学術雑誌論文
言語	英語
OAI-PMH Set	岡山大学
著作権者	© The Author(s) 2024
論文のバージョン	publisher
PubMed ID	39841323
DOI	10.1007/s11060-024-04925-7
Web of Science KeyUT	001401916600001
関連URL	isVersionOf https://doi.org/10.1007/s11060-024-04925-7
ライセンス	http://creativecommons.org/licenses/by/4.0/
Citation	Umeda, T., Otani, Y., Fujii, K. et al. Identification of factors related to functional prognoses in craniopharyngiomas. J Neurooncol (2025). https://doi.org/10.1007/s11060-024-04925-7
助成機関名	Ministry of Education, Culture, Sports, Science and Technology Okayama University
助成番号	22K16687