ID | 30984 |
JaLCDOI | |
フルテキストURL | |
著者 |
Lin, Qiang
Hebei Medical University Fourth Hospital
Gao, Xian-Shu
Hebei Medical University Fourth Hospital
Qiao, Xue-Ying
Hebei Medical University Fourth Hospital
Zhou, Zhi-Guo
Hebei Medical University Fourth Hospital
Zhang, Ping
Hebei Medical University Fourth Hospital
Chen, Kun
North China Petroleum Bureau General Hospital
Zhao, Yan-Nan
North China Petroleum Bureau General Hospital
|
抄録 | We defined the maximum-tolerated dose (MTD) of chemoradiotherapy (cisplatin (CDDP) with 5-fluorouracil (5-FU) and concurrent chemoradiotherapy) for Chinese patients with esophageal cancer. Twenty-one previously untreated patients with primary esophageal cancer were entered into this study. Escalating doses of CDDP with 5-FU were administered in a modified Fibonacci sequence, with concurrent conventional fractionation radiotherapy (CFR) of 60 Gy or 50 Gy. The starting doses were CDDP 37.5 mg/m2 on day 1, and 5-FU 500 mg/m2 on days 1-5, respectively. The regimen was repeated 4 times every 28 days. If no dose-limiting toxicity (DLT) was observed, the next dose level was applied. The procedures were repeated until DLT appeared. The MTD was declared to be 1 dose level below the level at which DLT appeared. DLT was grade 3 radiation-induced esophagitis at a dose level of CDDP 60 mg/m2 with 5-FU 700 mg/m2 and concurrent 60 Gy CFR. MTD was defined as CDDP 52.5 mg/m2 with 5-FU 700 mg/m2 and concurrent 50 Gy CFR. The MTD of CDDP with 5-FU and in concurrent chemoradiotherapy for Chinese patients with esophageal cancer is CDDP 52.5 mg/m2 on day 1 and 5FU 700 mg/m2 on days 1-5, repeated 4 times every 28 days, and concurrent 50 Gy CFR. Further evaluation of this regimen in a prospective phase II trial is ongoing. |
キーワード | esophageal neoplasm
concurrent chemoradiotherapy
cisplatin
5-fluorouracil
dose escalation
|
Amo Type | Original Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 2008-02
|
巻 | 62巻
|
号 | 1号
|
出版者 | Okayama University Medical School
|
開始ページ | 37
|
終了ページ | 44
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
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PubMed ID | |
Web of Science KeyUT |