ID | 56895 |
Sort Key | 4
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タイトル(別表記) | Reactivity of secretory immunoglobulin A against gut bacteria is attenuated by high-fat diet consumption
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フルテキストURL | |
著者 |
MUHOMAH, Teresia Aluoch
岡山大学大学院環境生命科学研究科
園山 慶
北海道大学大学院農学研究院
西野 直樹
岡山大学大学院環境生命科学研究科
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抄録 | Secretory immunoglobulin A (SIgA) is predominant antibody secreted into the gut relating to maintain gut homeostasis. In the present study, we focused on the SIgA coating of gut bacteria as a mucosal immune response affecting the gut bacteria following a high-fat diet (HFD). This study newly showed that the level of SIgA coating of gut bacteria was significantly decreased in HFD-fed mice than normal-fat diet (NFD)-fed mice. Furthermore, we found that the relative abundances of gut bacteria were significantly negatively or positively correlated with the level of SIgA coating of gut bacteria in NFD-fed and HFD-fed mice. Our observations suggest that a decrease in the level of SIgA coating of the gut bacteria through a HFD might relate to HFD-induced changes in bacterial composition.
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備考 | 記念講演要旨(Summary of Commemorational Lecture)
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出版物タイトル |
岡山実験動物研究会報
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発行日 | 2019-06
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巻 | 35巻
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出版者 | 岡山実験動物研究会
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出版者(別表記) | Okayama Association for Laboratory Animal Science
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開始ページ | 9
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終了ページ | 11
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資料タイプ |
会議発表論文
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OAI-PMH Set |
岡山大学
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言語 |
日本語
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論文のバージョン | publisher
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Eprints Journal Name | poalas
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