ID | 17261 |
Eprint ID | 17261
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フルテキストURL | |
タイトル(別表記) | Effects of antilymphocyte serum on various reactions of lymphocytes
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著者 |
小川 潔
岡山大学医学部第一外科教室
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抄録 | Using phytohemagglutinin (PHA) and/or Antilymphocyte serum (ATS) that are considered to act only on T-lymphocytes, a study was made of the effects of these substances on pleque forming cells (PFC) for sheep red cells in spleen of mice and the antitumor activity of cancerbearing mice as well as the blastformation rate of mouse lymphocytes against PHA in vitro, and the following results were obtained. 1) From the fact that PFC proliferate in the presence of PHA but they decrease in number in the presence of ATS, PFC seem to be under the control of T-cells. 2) As the antitumor effects of cancer-bearing mouse lymphocytes is enhanced by PHA but it is decreased by ATS, it may be said that T-cells play a leading role in the antitumor immunity as efector cells. 3) Since MIF activity of cancer-bearing mouse is decreased markedly by ATS, it seems that T-cells play the most important role in producing MIF. 4) Since the blastformation rate of mouse lymphocytes against PHA decreases in the presence of ATS, it may be assumed that the lymphocytes undergoing blastformation are T-cells. Various roles of T-cells are now being clacified, while the present experiment is a step toward the clacification of such roles.
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発行日 | 1977-12-30
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出版物タイトル |
岡山医学会雑誌
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出版物タイトル(別表記) | Journal of Okayama Medical Association
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巻 | 89巻
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号 | 11-12号
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出版者 | 岡山医学会
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出版者(別表記) | Okayama Medical Association
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開始ページ | 1537
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終了ページ | 1547
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ISSN | 0030-1558
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NCID | AN00032489
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資料タイプ |
学術雑誌論文
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オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/89/11-12/89_11-12_1537/_article/-char/ja/
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関連URL | http://www.okayama-u.ac.jp/user/oma/
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言語 |
日本語
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著作権者 | 岡山医学会
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論文のバージョン | publisher
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査読 |
有り
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Eprints Journal Name | joma
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