ID | 13753 |
Eprint ID | 13753
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フルテキストURL | |
タイトル(別表記) | Serum neuron specific enolase (NSE) level in patients with advanced non-small cell lung cancer (NSCLC) treated with chemotherapy : A possible prognostic indicator
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著者 |
肥山 淳一郎
岡山大学医学部第二内科学教室
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抄録 | In an attempt to elucidate the clinical sigificance of serum NSE leval in patients with advaced NSCLC, I determined the pretreatment serum NSE levels in 154 patients who received chemotherapy. Of them, 45(29%) showed an elevated leved of ≧ 10ng/ml. Patients with elevated NSE level were significantly more frequent in stage Ⅳ than in stage Ⅲ. The median duration of response to chemotherapy was significantly shorter in patient with an elevated level than in those with a non-elevated level (4.9 months vs 6.7 months ; p<0.05). Patients showing an elevated NSE level survived significantly shorter than those showing a non-elevated level (6.2 months vs 13.1 months ; p<0.001). A multivariate analysis revealed that the pretreatment NSE level, clinical stage, and pretreatment serum albumin level were independent prognostic factors in patients with advanced NSCLC receiving chemotherapy. Additionally, I stained 46 tumor specimens histochemically using the anti- NSE antibody. However, the stainability did not correlate with the serum NSE level. These findings indicate that the elevated NSE in the sera did not originate in the expression of neuroendocrine nature of NSCLC tumors but in the bulk of tumors and cell kinetic characterisitics. e. g., rapid growth with large cell death.
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キーワード | Neuron-specific enolase
Non small cell lung cancer
Chemotherapy
Immunohistochemistry
Prognostic factor
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備考 | 原著
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発行日 | 1995-10-31
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出版物タイトル |
岡山医学会雑誌
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出版物タイトル(別表記) | Journal of Okayama Medical Association
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巻 | 107巻
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号 | 9-10号
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出版者 | 岡山医学会
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出版者(別表記) | Okayama Medical Association
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開始ページ | 179
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終了ページ | 186
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ISSN | 0030-1558
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NCID | AN00032489
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資料タイプ |
学術雑誌論文
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オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/107/9-10/107_9-10_179/_article/-char/ja/
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関連URL | http://www.okayama-u.ac.jp/user/oma/index.html
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言語 |
日本語
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著作権者 | 岡山医学会
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論文のバージョン | publisher
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査読 |
有り
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Eprints Journal Name | joma
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