ID | 31813 |
JaLCDOI | |
フルテキストURL | |
著者 |
Kobayashi, Koichiro
Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ogasawara, Masahiro
Department of Hematology, Sapporo Hokuyu Hospital
Kiyama, Yoshio
Department of Hematology, Sapporo Hokuyu Hospital
Miyazono, Takayoshi
Department of Hematology, Sapporo Hokuyu Hospital
Kagawa, Kumiko
Department of Hematology, Sapporo Hokuyu Hospital
Imai, Kiyotoshi
Department of Hematology, Sapporo Hokuyu Hospital
Hirano, Teiichi
Department of Hematology, Sapporo Hokuyu Hospital
Kobayashi, Naoki
Department of Hematology, Sapporo Hokuyu Hospital
Tanimoto, Mitsune
Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kaken ID
publons
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Kasai, Masaharu
Department of Hematology, Sapporo Hokuyu Hospital
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抄録 | A 23-year old woman with acute biphenotypic leukemia (ABL) complained of chest pain with cough, high fever and hemoptysis during induction chemotherapy, although she had been treated with anti-biotics and micafungin. We made a clinical diagnosis of invasive pulmonary aspergillosis (IPA) based on a consolidation in the right upper lung field on a chest radiograph as well as a high level of serum beta-D-glucan (with no evidence of tuberculosis and candidiasis). We changed her treatment from micafungin to voriconazole. Later, we discovered an air-crescent sign by CT scan that supported the diagnosis of IPA. Following voriconazole treatment, clinical symptoms ceased and abnormal chest shadows improved gradually and concurrently with a recovery of neutrophils. IPA must be considered in immunocompromised patients with pulmonary infiltrates who do not respond to broad-spectrum antibiotics. Serological tests and CT findings can aid in early diagnosis of IPA, which, along with treatment for IPA, will improve clinical outcomes. |
キーワード | invasive pulmonary aspergillosis
voriconazole
acute biphenotypic leukemia
febrile neutropenia
?-D-glucan
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Amo Type | Case Report
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出版物タイトル |
Acta Medica Okayama
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発行日 | 2009-08
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巻 | 63巻
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号 | 4号
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出版者 | Okayama University Medical School
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開始ページ | 213
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終了ページ | 216
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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論文のバージョン | publisher
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査読 |
有り
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PubMed ID | |
Web of Science KeyUT |