ID | 31702 |
JaLCDOI | |
フルテキストURL | |
著者 |
Yoshinouchi, Takeo
Nagoya City University
Ohtsuki, Yuji
Kochi Medical School
Fujita, Jiro
Kagawa Medical University
Sugiura, Yoshiki
Nagoya City University
Banno, Shogo
Nagoya City University
Sato, Shigeki
Nagoya City University
Ueda, Ryuzo
Nagoya City University
|
抄録 | Pathologic features of Mycoplasma pneumoniae infection (M. pneumonia) are generally non-specific, and the literature regarding the pathologic features of M. pneumonia with intraalveolar exudates is limited. Clinical and histopathological studies were performed in 3 patients with M. pneumonia which did not respond to erythromycin and minocycline, but all rapidly recovered after corticosteroid therapy. In pathologic findings, we observed intraalveolar exudates and focal organization in M. pneumonia, and its intraalveolar lesions were compared between M. pneumonia and bronchiolitis obliterans organizing pneumonia containing fibrin (BOOP). Immunohistochemical studies were performed using the streptavidin biotin peroxidase complex method with anti-alpha-smooth muscle actin antibody and anti-pancytokeratin AE1/AE3 antibody. In pathologic findings, more fibrin deposits in intaalveolar lesions were observed in M. pneumonia than in BOOP. In intaalveolar lesions of M. pneumonia, a larger amount of nuclear debris, more neutrophils, and more erythrocytes were noted. Myofibroblasts were observed in the organization of BOOP, while in the intaalveolar lesions of M. pneumonia, myofibroblasts were not observed. These results suggest that M. pneumonia with intraalveolar exudates responds well to corticosteroid and its intraalveolar lesions apparently differed from those in BOOP. |
キーワード | exudate
fibrin
Mycoplasma pneumonia
organizing pneumonia
steroid therapy
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 2002-04
|
巻 | 56巻
|
号 | 2号
|
出版者 | Okayama University Medical School
|
開始ページ | 111
|
終了ページ | 116
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |