ID | 31724 |
JaLCDOI | |
フルテキストURL | |
著者 |
Watanabe, Kazuhide
Okayama University
Matsuka, Naoyuki
Okayama University
Okazaki, Masatoshi
Okayama University
Hashimoto, Yasuhiko
Okayama University
Araki, Hiroaki
Okayama University
Gomita, Yutaka
Okayama University
|
抄録 | The effects of immobilization stress on the pharmacokinetics of omeprazole were studied in rats. The immobilization stress for 30 or 60 min immediately after oral administration of the drug caused an increase in the time to reach the maximum concentration. However, such stress did not alter the area under the plasma concentration-time curve (AUC). When administered intravenously, the half-life during the elimination phase was significantly prolonged by 30 min of immobilization stress, but the AUC value remained unchanged. The intestinal propulsive activity was significantly decreased by immobilization stress. These findings suggest that immobilization stress reduces gastrointestinal motility. A resulting delay during the absorption phase of omeprazole occurs, although the degree of influence on overall pharmacokinetics is relatively insignificant. |
キーワード | omeprazole
pharmacokinetics
stress
immobilization
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 2002-02
|
巻 | 56巻
|
号 | 1号
|
出版者 | Okayama University Medical School
|
開始ページ | 19
|
終了ページ | 23
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
|
PubMed ID | |
Web of Science KeyUT |