ID | 31300 |
JaLCDOI | |
フルテキストURL | |
著者 |
Yoshida, Atushi
Okayama University
Sotozono, Masaaki
Okayama University
Nakatou, Tatsuaki
Okayama Univeristy
Okada, Yoshio
Okayama Prefectural University
Tsuji, Takao
Okayama Prefectural University
|
抄録 | Thomsen-Friedenreich antigen (T antigen) has been supposed to be a cancer-specific carbohydrate antigen. We have previously shown that one third of the Japanese population normally expressed T antigen in gastric surface epithelia and the other two thirds expressed fucosyl-T antigen. Their sialylation and blocked-synthesis were associated with diseased conditions. In the present study, we studied gastric surface epithelial expression of monosaccharide antigen Tn, i.e., a precursor of T antigen, and sialyl-Tn. Normal fundic and pyloric epithelia, respectively, expressed Tn supranucleally and cytoplasmically, but did not express sialyl-Tn. In the intestinal metaplasias and intestinal-type adenomas, goblet cells expressed sialyl-Tn in their vacuoles, and absorptive cells expressed Tn apically. In gastric-type adenomas, Tn, but not sialyl-Tn, was detected. Intestinal-type cancers expressed Tn and sialyl-Tn more often than the diffuse-type cancers. Five cancers did not express Tn, sialyl-Tn, or the T-related antigens. In these, four were diffuse-type cancers. We concluded that: a) normal gastric epithelial cells express Tn; b) metaplastic differentiation is associated with sialylation of Tn and c) expression of Tn and sialyl-Tn is depressed in the gastric cancers. |
キーワード | Tn
immunohistochemistru
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1998-08
|
巻 | 52巻
|
号 | 4号
|
出版者 | Okayama University Medical School
|
開始ページ | 197
|
終了ページ | 204
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
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PubMed ID | |
Web of Science KeyUT |