ID | 30876 |
JaLCDOI | |
フルテキストURL | |
著者 |
Jitsunari, Fumihiko
Kagawa Medidical School
Asakawa, Fumiyuki
Kagawa Medical School
Nakajima, Taichi
Kagawa Medical School
Shimada, Junko
Maeda Hospital
Ogata, Masana
Okayama University
|
抄録 | Chlorpyrifos, an organophosphorus insecticide, has been used to control termites since regulatory measures against the use of chlordanes were taken in September, 1986. We developed an improved gas chromatographic (GC) method for the assay of 3,5,6-trichloro-2-pyridinol (TCP) in the urine to use in the biological monitoring of exposure to chlorpyrifos. Urinary TCP was separated and determined accurately (C.V., 4%) with high sensitivity (detection limit, 10 ng/ml) and recovery (recovery greater than 90%) using a wide bore capillary column (WBC column). The accuracy and precision of the present GC method are satisfactory. The time course of urinary excretion of TCP was followed in workers. The urinary TCP level was low in the off-season and high in the busy season. Variation in the urinary TCP level corresponded to the termite control season and the length of the working period. The urinary TCP level showed a change reciprocal to the variations in the plasma cholinesterase activity. From these results, it is surmised that the urinary TCP level represents the extent of exposure to chlorpyrifos. The decrease in the level of cholinesterase activity is suggested to be due to exposure to chlorpyrifos. Determination of the urinary TCP level by GC using a WBC column is useful in the biological monitoring of chlorpyrifos in termite control workers and potentially has practical application to health care. |
キーワード | termite control worker
chlorpyrifos
urinary 3
5
6-trichloro-2-pyridinol
biological exposure index
biological monitoring
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1989-10
|
巻 | 43巻
|
号 | 5号
|
出版者 | Okayama University Medical School
|
開始ページ | 299
|
終了ページ | 306
|
ISSN | 0386-300X
|
NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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論文のバージョン | publisher
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査読 |
有り
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PubMed ID | |
Web of Science KeyUT |