ID | 30868 |
JaLCDOI | |
フルテキストURL | |
著者 |
Miyashima, Takanao
Okayama University
Hayashi, Keiki
Okayama University
Awai, Michiyasu
Okayama University
|
抄録 | To clarify the initiation, development and recovery processes of disseminated intravascular coagulation (DIC), rat glomerular capillaries and fibrin thrombi were examined under transmission and scanning electron microscopes. DIC was induced in rats by a single intraperitoneal injection of endotoxin (Et., 7.5 mg/kg lipopolysaccharide:B, E. coli 026:B6). At 2 h after Et. injection, the endothelial surface of the glomerular capillary became irregular with projections like a sea anemone. At 4 h after Et. injection, agglomerated fibrin thrombi composed of fibrin fiber bundles with fine cross-striated fibriform structures were observed in the capillary lumen. The fibrin thrombi gradually changed into fine reticular systems suggesting a degradation process by 6 h after Et. injection, and formed a coarse granular agglomerate by 8 h after Et. injection. These fibrin thrombi disappeared within 12 h of Et. injection, but the endothelial surface remained edematous. At 24 h after Et. injection, the microstructure of the glomerular capillaries returned normal. Based on these observations, we concluded that DIC was primarily initiated by injury to the capillary endothelium, and that changes on the endothelial surface contributed to the development of DIC. |
キーワード | disseminated intravascular coagulation
renal tissue
electron microscope
rat
|
Amo Type | Article
|
出版物タイトル |
Acta Medica Okayama
|
発行日 | 1989-04
|
巻 | 43巻
|
号 | 2号
|
出版者 | Okayama University Medical School
|
開始ページ | 115
|
終了ページ | 126
|
ISSN | 0386-300X
|
NCID | AA00508441
|
資料タイプ |
学術雑誌論文
|
言語 |
英語
|
論文のバージョン | publisher
|
査読 |
有り
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PubMed ID | |
Web of Science KeyUT |