ID | 53518 |
フルテキストURL | |
著者 |
高取 真吾
日本新薬創薬研究所
合田 光寛
岡山大学大学院医歯薬学総合研究科臨床薬学分野
岩谷 有希子
岡山大学大学院医歯薬学総合研究科臨床薬学分野
Jin, Xin
岡山大学大学院医歯薬学総合研究科臨床薬学分野
Takada-Doi, Shima
山田養蜂場本社研究開発部
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抄録 | Royal jelly (RJ) is known to contain excellent nutrition and a variety of biological activities. The present study was designed to investigate the effects of RJ on insulin resistance (hyperinsulinemia) in fructose-drinking rats (FDR; insulin resistance animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin and triglyceride, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), and systolic blood pressure, but not blood glucose levels, when compared with control rats. RJ (100, 300mg/kg, p.o.) treatment for 8 weeks significantly decreased the plasma levels of insulin and triglyceride, HOMA-R, without affecting blood glucose or total cholesterol levels and tended to lower systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, RJ treatment resulted in a significant reduction in sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase the calcitonin gene-related peptide (CGRP) nervemediated vasodilator response to PNS, compared with those in untreated FDR. However, RJ treatment did not significantly affect norepinephrine-induced vasoconstriction or CGRP-induced vasodilation. These results suggest that RJ could be an effective functional food to prevent insulin resistance associated with the development of hypertension.
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キーワード | royal jelly
fructose-drinking rat
insulin resistance
periarterial nerve function
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備考 | コンテンツの著作権は日本薬学会が有します。
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発行日 | 2008-11-01
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出版物タイトル |
Biological & Pharmaceutical Bulletin
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巻 | 31巻
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号 | 11号
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出版者 | 日本薬学会
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出版者(別表記) | The Pharmaceutical Society of Japan
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開始ページ | 2103
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終了ページ | 2107
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ISSN | 09186158
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NCID | AA10885497
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | © The Pharmaceutical Society of Japan
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論文のバージョン | publisher
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査読 |
有り
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DOI | |
PubMed ID | |
Web of Science KeyUT |