フルテキストURL Biochem_Biophy_Res_Comm_201807.pdf
著者 Fujiwara, Toshifumi| Eguchi, Takanori| Sogawa, Chiharu| Ono, Kisho| Murakami, Jun| Ibaragi, Soichiro| Asaumi, Jun-ichi| Okamoto, Kuniaki| Calderwood, Stuart K.| Kozaki, Ken-ichi|
抄録 Genetic amplification, overexpression, and increased signaling from the epidermal growth factor receptor (EGFR) are often found in oral squamous cell carcinoma (OSCC) and thus EGFR is frequently targeted molecularly by the therapeutic antibody cetuximab. We assessed effects of cetuximab in control of EGF-driven malignant traits of OSCC cells. EGF stimulation promoted progression level of mesenchymal traits in OSCC cells, which were attenuated by cetuximab but incompletely. We pursued a potential mechanism underlying such incomplete attenuation of OSCC malignant traits. Cetuximab promoted secretion of EGFR-EVs by OSCC cells and failed to inhibit EGF-driven secretion of EGFR-EVs. Cetuximab was also found to be robustly secreted with the EGFR-EVs by the OSCC cells. Thus, EGF promotes the level of mesenchymal traits of OSCC cells and secretion of EGFR-EVs, which involve cetuximab resistance.
キーワード Extracellular vesicles Anti-EGFR antibody therapy Cetuximab Epithelial-to-mesenchymal transition Head and neck squamous cell carcinoma
発行日 2018-07-13
出版物タイトル Biochemical and Biophysical Research Communications A
出版者 Elsevier
ISSN 0006291X
NCID AA00564395
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 http://creativecommons.org/licenses/by-nc-nd/4.0/
論文のバージョン publisher
DOI 10.1016/j.bbrc.2018.07.035
関連URL isVersionOf https://doi.org/10.1016/j.bbrc.2018.07.035