ID | 57894 |
フルテキストURL | |
著者 |
Oka, Aiko
Department of Otorhinolaryngology, International University of Health and Welfare Graduate School of Medicine
Ninomiya, Takahiro
Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
Fujiwara, Tazuko
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Takao, Soshi
Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Sato, Yasuharu
Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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Gion, Yuka
Division of Pathophysiology, Okayama University Graduate School of Health Sciences
Minoura, Akira
Department of Hygiene, Public Health and Preventive Medicine, Showa University School of Medicine
Haruna, Shin-ichi
Department of Otorhinolaryngology, Head & Neck Surgery, Dokkyo Medical University
Yoshida, Naohiro
Department of Otolaryngology, Jichi Medical University Saitama Medical Center
Sakuma, Yasunori
Department of Otorhinolaryngology, Yokohama City Medical Center
Izuhara, Kenji
Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School
Ono, Junya
Shino-Test Co., Ltd.
Taniguchi, Masami
Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
Haruna, Takenori
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Higaki, Takaya
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Kariya, Shin
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Koyama, Takahisa
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Takabayashi, Tetsuji
Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
Imoto, Yoshimasa
Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
Sakashita, Masafumi
Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
Kidoguchi, Masanori
Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
Nishizaki, Kazunori
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Fujieda, Shigeharu
Department of Otorhinolaryngology Head & Neck Surgery, Faculty of Medical Sciences, University of Fukui
Okano, Mitsuhiro
Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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抄録 | Background: Type 2 chronic rhinosinusitis (CRS), especially eosinophilic CRS (ECRS), is an intractable upper airway inflammatory disease. Establishment of serum biomarkers reflecting the pathophysiology of CRS is desirable in a clinical setting. As IgG4 production is regulated by type 2 cytokines, we sought to determine whether serum IgG4 levels can be used as a biomarker for CRS.
Methods: Association between the serum IgG4 levels and clinicopathological factors was analyzed in 336 CRS patients. Receiver operating characteristics (ROC) analysis was performed to determine the cut-off value of serum IgG4 levels that can be used to predict the post-operative recurrence. Results: Serum IgG4 levels were significantly higher in patients with moderate to severe ECRS versus those with non to mild ECRS. The levels were also significantly higher in asthmatic patients and patients exhibiting recurrence after surgery compared to controls. ROC analysis determined that the best cut-off value for the serum IgG4 level to predict the post-operative recurrence was 95 mg/dL. The corresponding sensitivity and specificity were 39.7% and 80.5%, respectively. When we combined the two cut-off values for the serum IgG4 and periostin, patients with high serum levels of either IgG4 or periostin exhibited a high post-operative recurrence (OR: 3.95) as compared to patients having low serum levels of both IgG4 and periostin. Conclusions: The present results demonstrate that the serum IgG4 level is associated with disease severity and post-operative course in CRS. In particular, the combination of serum IgG4 and periostin could be a novel biomarker that predicts post-operative recurrence. |
キーワード | Chronic rhinosinusitis
Eosinophils
Eosinophils
IgG4
Severity
Surgery
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発行日 | 2020-01-14
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出版物タイトル |
Allergology International
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出版者 | Elsevier
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ISSN | 13238930
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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著作権者 | © 2019 Japanese Society of Allergology. Production and hosting by Elsevier B.V.
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論文のバージョン | publisher
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PubMed ID | |
DOI | |
関連URL | isVersionOf https://doi.org/10.1016/j.alit.2019.12.004
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ライセンス | http://creativecommons.org/licenses/by-nc-nd/4.0/
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Citation | Oka A, Ninomiya T, Fujiwara T, et al. Serum IgG4 as a biomarker reflecting pathophysiology and post-operative recurrence in chronic rhinosinusitis [published online ahead of print, 2020 Jan 14]. Allergol Int. 2020;S1323-8930(19)30201-1. doi:10.1016/j.alit.2019.12.004
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オープンアクセス(出版社) |
OA
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オープンアーカイブ(出版社) |
非OpenArchive
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