ID | 57574 |
フルテキストURL | |
著者 |
Wang, Yang
Graduate School of Environmental and Life Science , Okayama University
Hatabu, Toshimitsu
Graduate School of Environmental and Life Science , Okayama University
Kaken ID
researchmap
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抄録 | This study aimed to evaluate the microbial compositions and gene expression related to inflammation in dextran sodium sulfate (DSS)-induced acute colitis and the effect of mulberry supplementation. Male BALB/c mice received a diet supplemented with mulberry juice freeze-dried powder (MFP) or not for 3 weeks. After 3 weeks, the mice received water containing 5% (w/v) DSS or not for 1 week. The disease activity index score in mice fed MFP was significantly decreased. A significant decrease in Bifidobacterium spp. and the Clostridium perfringens subgroup was observed in mice not fed MFP. The number of goblet cell and NLRP6 expression were observed in mice fed a diet supplemented with MFP compared with mice not fed MFP. These results may indicate that mulberry mitigates DSS-induced acute colitis by a changing the gut microbial flora and by improving mucosal conditions.
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キーワード | DSS-induced acute colitis
Mulberry
NLRP6 inflammasome
goblet cell
microbiota
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備考 | This fulltext will be available in Feb 2020
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発行日 | 2019-02-17
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出版物タイトル |
Bioscience, Biotechnology and Biochemistry
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巻 | 83巻
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号 | 5号
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出版者 | TAYLOR & FRANCIS
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開始ページ | 914
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終了ページ | 922
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ISSN | 0916-8451
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NCID | AA10824164
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資料タイプ |
学術雑誌論文
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言語 |
英語
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OAI-PMH Set |
岡山大学
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論文のバージョン | author
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PubMed ID | |
DOI | |
Web of Science KeyUT | |
関連URL | isVersionOf https://doi.org/10.1080/09168451.2019.1580135
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