ID | 11746 |
Eprint ID | 11746
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フルテキストURL | |
タイトル(別表記) | 虚血後線状体に出現する神経前駆細胞の起源
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著者 |
山下 徹
岡山大学
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抄録 | Recent studies have revealed that the adult mammalian brain has the capacity to regenerate some neurons after various insults. However, the precise mechanism of insult-induced neurogenesis has not been demonstrated. In the normal brain, GFAP-expressing cells in the subventricular zone (SVZ) of the lateral ventricles include a neurogenic cell population that gives rise to olfactory bulb neurons only. Herein, we report evidence that, after a stroke, these cells are capable of producing new neurons outside the olfactory bulbs. SVZ GFAP-expressing cells labeled by a cell-type-specific viral infection method were found to generate neuroblasts that migrated toward the injured striatum after middle cerebral artery occlusion. These neuroblasts in the striatum formed elongated chain-like cell aggregates similar to those in the normal SVZ, and these chains were observed to be closely associated with thin astrocytic processes and blood vessels. Finally, long-term tracing of the green fluorescent-labeled cells with a Cre-loxP system revealed that the SVZ-derived neuroblasts differentiated into mature neurons in the striatum, in which they expressed neuronal-specific nuclear protein and formed synapses with neighboring striatal cells. These results highlight the role of the SVZ in neuronal regeneration after a stroke and its potential as an important therapeutic target for various neurological disorders.
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キーワード | zone
cerebral ischemia
migration
neurogenesis
regeneration
striatum
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備考 | http://dx.doi.org/10.1523/JNEUROSCI.0149-06.2006
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発行日 | 2007-03-23
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出版物タイトル | |
資料タイプ |
学位論文
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学位授与番号 | 甲第3322号
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学位授与年月日 | 2007-03-23
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学位・専攻分野 |
博士(医学)
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オフィシャル URL | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16775151&dopt=Abstract
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言語 |
日本語
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論文のバージョン | none
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査読 |
不明
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