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ID 2198
Eprint ID
2198
フルテキストURL
Thumnail K001945.pdf 161 KB
タイトル(別表記)
実験的高血圧モデルにおける陰茎血管の構造変化について
著者
岡部 浩典 岡山大学
抄録
In hypertension, small arteries in a variety of vascular beds undergo structural changes that increase resistance. To assess whether there are differential structural changes in the penis that accompany hypertension, we began with determining structurally-based vascular resistance properties in penile and hindlimb vascular beds of adult spontaneously hypertensive rats (SHR) and Sprague-Dawley (SD) rats. In anesthetized SHR, the penile and hindlimb vasculature were isolated and perfused, maximum dilation was induced, and a flow-pressure assessment and alpha 1-adrenoceptor agonist concentration-response curves were generated. Both the baseline and maximum constrictor responses were similar in the two beds of each strain, and overall the maximum structurally-based vascular resistance in SHR was higher than in SD rats. Our data suggests that the penile vasculature is not protected from the structural changes that take place in the other vascular beds in hypertension. There does not appear to be an underlying functional control mechanism that protects the penile vasculature from structural changes that may have a negative impact on penile blood flow.
キーワード
erectile dysfunction
hypertension
structural change
penile vasculature
spontaneously hypertensive rats
備考
掲載順位 73 ; http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10404281&dopt=Abstract
発行日
1999-03-31
出版物タイトル
資料タイプ
学位論文
学位授与番号
甲第1945号
学位授与年月日
1999-03-31
学位・専攻分野
博士(医学)
授与大学
岡山大学
オフィシャル URL
http://www.nature.com/ijir/journal/v11/n3/pdf/3900394a.pdf
言語
Japanese
論文のバージョン
none
査読
不明