Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Action mechanisms of complex spa therapy on bronchial asthma. 3. Relationship to airway inflammation

保崎 泰弘 岡山大学医学部附属病院三朝分院内科
御舩 尚志 岡山大学医学部附属病院三朝分院内科
光延 文裕 岡山大学医学部附属病院三朝分院内科 Kaken ID publons researchmap
芦田 耕三 岡山大学医学部附属病院三朝分院内科 Kaken ID researchmap
横田 聡 岡山大学医学部附属病院三朝分院内科
柘野 浩史 岡山大学医学部附属病院三朝分院内科
竹内 一昭 岡山大学医学部附属病院三朝分院内科
名和 由一郎 岡山大学医学部附属病院三朝分院内科
谷崎 勝朗 岡山大学医学部附属病院三朝分院内科
越智 浩二 岡山大学医学部臨床検査医学
原田 英雄 岡山大学医学部臨床検査医学
The degree and characteristic of airway inflammation were evaluated by the proportions of bronchoalveolar lavage (BAL) cells. Clinical asthma types such as Ia. simple bronchoconstriction, Ib. bronchoconstriction + hypersecretion, and Ⅱ. bronchiolar obstruction correlate with airway inflammation. The increased proportion BAL neutrophils is characteristic of type Ⅱ asthma, and increase in BAL eosinophil count is often observed in type Ib asthma. Bronchial hyperresponsiveness also correlates with airway inflammation. Action of spa therapy has been speculated to be related to airway inflammation, since the therapy has no action inhibiting IgE-mediated allergic reaction. In fact, spa therapy is more effective in patients with type Ib and type Ⅱ than in those with type Ia showing slight degree of airway inflammation. Bronchial hyperresponsiveness is also improved by spa therapy. From a point of view, the direct action of spa therapy may be to clean airways and improve damaged mucous membrane of the airways, leading to suppression of airway inflammation.
Spa therapy (温泉療法)
Airway inflammation (気道炎症反応)
BAL eosinophilia (BAL好酸球増多)
BAL neutrophilia (BAL好中球増多)
Bronchial asthma (気管支喘息)