コレステロール型肺炎の成因に関する研究

Clinicopathological and experimental studies were performed to clarify the genesis of primary lipoid pneumonia. Complete examination of resected lungs from six cases, which were believed to be suitable for this entity, were made. In addition to characteristic pathologic changes such as massive appearance of intralveolar foam cells, peribronchial and perivascular inflammation and interstitial fibrosis, definite changes of pulmonary arteries and veins of various size were noted. Pathologic changes in vessels were most prominent especially in the arteries of small and medium size. Definite narrowing of the lumen due to swelling of intima and thickening and swelling of both media and adventitia were noted. These changes were minimum in the large arteries. Occlusion due to thrombus was noted only in one case of medium sized artery. Based on these findings, experimental studies were undertaken to produce the similar pathologic changes in the lungs of dogs and rabbits. Experimental animals were divided into eight groups, where different experimental procedures were applied as follows. Ligation, to cause either occlusion or stenosis of pulmonary artery, vein or bronchus, was performed in five groups of dogs. Vasopression was injected daily for 30 successive days with the dose of 0.5cc. per kilogram of body weight in another group of rabbits. Intrapulmonary inoculation of Staphylococcus aureus was made with 0.3cc. of the bacterial suspension, containing 10mg. of the bacteria in 1cc. of physiologic saline, to induce pulmonary infection, directly through the thoracic wall. The other group of rabbit was fed daily with chow containing 1gm. of cholesterol for 30 days.