Acta Medica Okayama 74巻 2号
2020-04 発行
Thar Htet San
Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ota, Yoko
Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Fushimi, Soichiro
Department of Pathology, Himeji Red Cross Hospital
Fujisawa, Masayoshi
Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
Yanai, Hiroyuki
Department of Pathology, Okayama University Hospital
Toda, Hiroko
Section of Diagnostic Pathology, Fukuyama Medical Association
Kunitomo, Tadayoshi
Department of Pathology, Kurashiki Medical Center
Kodama, Keisuke
Department of Gynecology, Kurashiki Medical Center
Matsukawa, Akihiro
Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
ORCID
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Juvenile granulosa cell tumors (JGCTs) are rare ovarian tumors with overall good prognoses. They differ from adult granulosa cell tumors (AGCTs), which are well known for late recurrence. Most JGCTs (~97%) occur in individuals <30 years old. We report a recurrent JGCT in a 40-year-old woman 5 years after initial presentation. The histological appearance and lack of 402C>G missense point mutation of FOXL2 gene (characteristic of AGCT but absent in JGCT) allowed differentiation from AGCT. This is the first comprehensive report of JGCT with late recurrence. Although rare, late recurrence of JGCT can occur; long-term surveillance is suggested.
juvenile granulosa cell tumor
late recurrence
adult granulosa cell tumor