ID | 53517 |
フルテキストURL | |
タイトル(別表記) | Effect of propolis on insulin resistance in fructose-drinking rats
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著者 |
高取 真吾
日本新薬創薬研究所
合田 光寛
岡山大学大学院医歯薬学総合研究科臨床薬学分野
岩谷 有希子
岡山大学大学院医歯薬学総合研究科臨床薬学分野
土井 志真
山田養蜂場本社研究開発部
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抄録 | Propolis, a honeybee product, contains a variety of biologically active substances. The present study was designed to investigate the effects of propolis on insulin resistance induced by fructose-drinking rats (FDR; type 2 diabetic animal model). Male Wistar rats (6 weeks old) received 15% fructose solution in drinking water for 8 weeks. FDR showed significant increases in plasma levels of insulin, Homeostasis Model Assessment ratio (HOMA-R, an index of insulin resistance), body weight, and systolic blood pressure but not blood glucose levels, when compared with control rats. Brazilian propolis extract (100 and 300mg/kg, p. o.) treatment for 8 weeks significantly decreased the plasma level of insulin, HOMA-R, and body weight, increased plasma triglyceride levels without affecting blood glucose and total cholesterol levels, and tended to decrease systolic blood pressure. In isolated and perfused mesenteric vascular beds of FDR, propolis treatment resulted in a significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS; 8Hz) and tended to increase the calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS, compared with those in untreated FDR. However, propolis treatment did not significantly affect norepinephrine-induced vasoconstriction and CGRP-induced vasodilation. These results suggest that propolis could be an effective functional food to prevent the development of insulin resistance.
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キーワード | propolis
fructose-drinking rat
insulin resistance
periarterial nerve function
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備考 | コンテンツの著作権は日本薬学会が有します。
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発行日 | 2007-12-01
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出版物タイトル |
藥學雜誌
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出版物タイトル(別表記) | Yakugaku zasshi
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巻 | 127巻
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号 | 12号
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出版者 | 日本薬学会
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出版者(別表記) | The Pharmaceutical Society of Japan
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開始ページ | 2065
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終了ページ | 2073
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ISSN | 00316903
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NCID | AN00284903
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資料タイプ |
学術雑誌論文
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言語 |
日本語
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著作権者 | 日本薬学会
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論文のバージョン | publisher
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査読 |
有り
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DOI | |
PubMed ID | |
Web of Science KeyUT |