ID | 30009 |
フルテキストURL | |
著者 |
Hanafusa, Tadashi
Okayama University Advanced Science Research Center, Department of Radiation Research, Shikata Laboratory
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Shinji, Toshiyuki
Department of Laboratory Medicine, Okayama University Graduate School of Medicine and Dentistry
Shiraha, Hidenori
First Department of Internal Medicine, Okayama University Graduate School of Medicine and Dentistry
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Nouso, Kazuhiro
First Department of Internal Medicine, Okayama University Graduate School of Medicine and Dentistry
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Iwasaki, Yoshiaki
First Department of Internal Medicine, Okayama University Graduate School of Medicine and Dentistry
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Yumoto, Eichiro
First Department of Internal Medicine, Okayama University Graduate School of Medicine and Dentistry
Ono, Toshiro
Okayama University Advanced Science Research Center, Department of Radiation Research, Shikata Laboratory
Kaken ID
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Koide, Norio
Department of Laboratory Medicine, Okayama University Graduate School of Medicine and Dentistry
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抄録 | Background: Insulin-like growth factor binding protein (IGFBP)-3 functions as a carrier of insulinlike
growth factors (IGFs) in circulation and a mediator of the growth suppression signal in cells. There are two reported p53 regulatory regions in the IGFBP3 gene; one upstream of the promoter and one intronic. We previously reported a hot spot of promoter hypermethylation of IGFBP-3 in
human hepatocellular carcinomas and derivative cell lines. As the hot spot locates at the putative upstream p53 consensus sequences, these p53 consensus sequences are really functional is a question to be answered. |
備考 | Digital Object Identifer:10.1186/1471-2407-5-9
Published with permission from the copyright holder. This is the institute's copy, as published in BMC Cancer, 20 January 2005, 5:9. Publisher URL:http://dx.doi.org/10.1186/1471-2407-5-9 © 2005 Hanafusa et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
発行日 | 2005-01-20
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出版物タイトル |
BMC Cancer
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巻 | 5巻
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出版者 | BioMed Central
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ISSN | 1471-2407
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NCID | AA12034763
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | Hanafusa et al; licensee BioMed Central Ltd.
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論文のバージョン | publisher
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査読 |
有り
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DOI | |
PubMed ID | |
Web of Science KeyUT | |
Submission Path | surgery/2
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