ID | 17195 |
Eprint ID | 17195
|
フルテキストURL | |
タイトル(別表記) | Influence of differential hypothermia on Vx2 tumor transplanted in rabbit Part 2. Tissue levels of anti-tumor agent during differential hypothermia
|
著者 |
山田 修
岡山大学脳神経外科教室
|
抄録 | The effect of differential hypothermia (D.H.) combined with anti-tumor agent, 5-fluorouracil (5-FU), was described in the previous report (Part 1). In this study, the tissue levels of 5-FU in the tumor and other organs during D.H. treatment were examined by bioassay method. At first, using Vx2 tumors transplanted into the bilateral ears of the rabbits, D.H. treatment was performed with the same procedures as Part 1. The tissue level of 5-FU in the tumors, detected 45 minutes after administration, was the highest in the D.H.-treated tumors (22.1μg/g), as compared with contra-lateral, hypothermic tumors (11.4μg/g) and non-treated, normothermic tumors (6.8μg/g). The tissue level of 5-FU in other organs such as lung, kidney, skin, liver and brain was low in both hypothermic and normothermic conditions. But blood level of 5-FU was kept relatively high during generalized hypothermia (1hr.; 150μg/ml, 2hrs.; 10.4μg/ml), as compared with normothermia (1hr.; 5.5μg/ml, 2hrs.; 0.5μg/ml). The author further investigated that the tissue level of 5-FU in the brain tumors (Vx2 tumors transplanted into the brain of rabbit) was affected with D.H. treatment. In this experiment, the tumors were kept normothermic by irradiation of 2.45 GHz microwave under general body coiling. The D.H. treated brain tumors revealed higher level of 5-FU (19.6μg/g) than the nontreated brain tumors (6.4μg/g).
|
発行日 | 1978-02-28
|
出版物タイトル |
岡山医学会雑誌
|
出版物タイトル(別表記) | Journal of Okayama Medical Association
|
巻 | 90巻
|
号 | 1-2号
|
出版者 | 岡山医学会
|
出版者(別表記) | Okayama Medical Association
|
開始ページ | 47
|
終了ページ | 57
|
ISSN | 0030-1558
|
NCID | AN00032489
|
資料タイプ |
学術雑誌論文
|
オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/90/1-2/90_1-2_47/_article/-char/ja/
|
関連URL | http://www.okayama-u.ac.jp/user/oma/index.html
|
言語 |
日本語
|
著作権者 | 岡山医学会
|
論文のバージョン | publisher
|
査読 |
有り
|
Eprints Journal Name | joma
|