ID | 16001 |
Eprint ID | 16001
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フルテキストURL | |
タイトル(別表記) | Electron microscopic study of the hippocampal formation of rats after picrotoxin administration
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著者 |
渡辺 弘樹
岡山大学医学部第一解剖学教室
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抄録 | Changes in the granule cells of the rat dentate gyrus, hippocampal mossy fibers and moosy fiber boutons following administration of picrotoxin were examined at the ultrastructual level. In controls, many small round clear vesicles (20-40 nm in diameter) along with a small number of large dense-core vesicles (60-90 nm in diameter) filled the mossy fiber boutons. Following administration of picrotoxin, the large dense-core vesicles increased in number and accumulated on the presynaptic membrane. Some of the large dense-core vesicles appeared to be fused with the membrane and frequently exhibited omega-shaped exocytotic profiles. A greatly increased number of coated vesicles (60-90 nm in diameter) was observed on the maturing face of the Golgi fields in the cytoplasm of granule cells after injection of picrotoxin. In addition, the ends of the Golgi cisternae rods occasionally appeared to be coated, and coated large dense-core vesicles (60-80 nm in diameter) were seen in the mossy fibers. This study showed not only an increased incidence of large dense-core vesicle exocytosis during seizures, but also suggests that these vesicles are replaced in excess from the perikaryon.
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キーワード | picrotoxin
hippocampus
coated vesicle
large dense-core vesicle
electron microscopy
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発行日 | 1987-10-31
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出版物タイトル |
岡山医学会雑誌
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出版物タイトル(別表記) | Journal of Okayama Medical Association
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巻 | 99巻
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号 | 9-10号
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出版者 | 岡山医学会
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出版者(別表記) | Okayama Medical Association
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開始ページ | 1101
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終了ページ | 1116
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ISSN | 0030-1558
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NCID | AN00032489
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資料タイプ |
学術雑誌論文
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オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/99/9-10/99_9-10_1101/_article/-char/ja/
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関連URL | http://www.okayama-u.ac.jp/user/oma/index.html
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言語 |
日本語
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著作権者 | 岡山医学会
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論文のバージョン | publisher
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査読 |
有り
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Eprints Journal Name | joma
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