REPO

Annual Reports of Misasa Medical Center, Okayama University volume75
2004-12-01 発行

長期間喫煙による気管支唱息,肺気腫の病態的変化

Mitsunobu, Fumihiro Kaken ID publons researchmap
Hosaki, Yasuhiro
Ashida, Kozo Kaken ID researchmap
Hamada, Masanori
Iwagaki, Naofumi
Fujii, Makoto
Takata, Shingo Kaken ID publons
Tanizaki, Yoshiro
Publication Date
2004-12-01
Abstract
The influence of long-term cigarette smoking on the pathophysiology of chronic respiratory diseases with obstructive ventilatory dysfunction was discussed in patients with asthma and pulmonary emphysema (PE). 1. In patients with asthma, significant differences in the pathophysiology of the disease were observed between smokers and nonsmokers. A positive RAST score against inhalant allergens, bronchial hyperresponsiveness, and LTB4 generation by leucocytes were significantly more increased in smokers than in nonsmokers. The values of FEV1/FVC and OLco were significantly more decreased, and % RV was significantly more increased in smokers than in nonsmokers. 2. In comparison of asthma with PE, IgE-mediated allergy was significantly more increased in smokers with asthma than in nonsmokers with asthma and in smokers with PE. The values of % FEV1, FEVl %, and % OLco were significantly higher in nonsmokers with asthma than in smokers with PE, however, the % OLco and % RV were not significantly different between smokers with asthma and those with PE. The % LAA of the lungs on HRCT was larger in patients with PE than in smokers and nonsmokers with asthma. The results suggest that cigarette smoking influences the pathophysiology of asthma and PE.
Keywords
cigarette smoking (喫煙)
pulmonary function (肺機能)
hyperinflation (肺の過膨張)
asthma (喘息)
pulmonary emphysema (肺気腫)
ISSN
1348-1258
NCID
AA11840279
NAID