Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

海馬内gabaculine注入による扁桃核キンドリング発作の抑制効果

Ogawa, Toshihiko
Thumnail 97_29.pdf 1.82 MB
Abstract
Effects of intra-hippocampal administration of gabaculine, a GABA aminotransferase inhibitor, on kindled amygdaloid seizure were examined in rats. In addition, changes in regional brain GABA content after gabaculine administration were determined. Intra-hippocampal administration of gabaculine has a dose-dependent anticonvulasnt effect on kindled amygdaloid seizure. The anticonvulsant effect of gabaculine (0.92μg/2μl) was observed within only 24 hours of the gabaculine administration. Further, a significant increase in the GABA level in the ventral mibdrain region was observed within only 24 hours of the gabaculine (0.92μg/2μl) administration. The suppression of amygdaloid kindled seizures after intra-hippocampal administration of gabaculine may be due to the elevation of the GABA level in the ventral midbrain rather than in the hippocampus.
Keywords
amygdaloid kindling
GABA
gabaculine
hippocampus
ventral midbrain
ISSN
0030-1558
NCID
AN00032489