Suppression of amygdaloid kindled seizure by intra- hippocampal gabaculine administration

Effects of intra-hippocampal administration of gabaculine, a GABA aminotransferase inhibitor, on kindled amygdaloid seizure were examined in rats. In addition, changes in regional brain GABA content after gabaculine administration were determined. Intra-hippocampal administration of gabaculine has a dose-dependent anticonvulasnt effect on kindled amygdaloid seizure. The anticonvulsant effect of gabaculine (0.92μg/2μl) was observed within only 24 hours of the gabaculine administration. Further, a significant increase in the GABA level in the ventral mibdrain region was observed within only 24 hours of the gabaculine (0.92μg/2μl) administration. The suppression of amygdaloid kindled seizures after intra-hippocampal administration of gabaculine may be due to the elevation of the GABA level in the ventral midbrain rather than in the hippocampus.