Studies on experimental damage of the liver by ethanol and pyrazole Part. 1 Morphology of the liver and liver function tests

After administration of ethanol and pyrazole, a patient inhibitor of alcohol dehydrogenase, for 3 weeks to rats, histological changes, liver function tests and triglyceride contents of the liver were examined. Centrilobular zonal cell necrosis, remarkable eosinophilic degeneration, nuclear changes and fat deposition were found. Significant elevation of alkaline phosphatase was observed. Furthermore, there was retardation of growth. From these results, the marked liver damage produced by combination of ethanol and pyrazole can be atributed to the hormonal effect of a relatively high concentration of ethanol on liver cells and the combined effect of ethanol and pyrazole on liver cell microsomes.