Histopathological Study of Acute Renal Failure (ARF): Ⅱ. Course of histocytopathologic changes in experimental ischemic kidney

Much is yet to be understood about symptom development in acute renal failure (ARF). The author designed an animal experiment to investigate the factors involved in the progress of renal ischemia to ARF. The course of tissue damage and subsequent repair of kidney tissue of domestic rabbits following 90 minutes of induced ischemia was observed light and electron microscopically. The results suggested that ischemia is followed by DIC which then progresses to ARF. The degree of DIC seemed to affect the severity of renal dysfunction.