Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

Pathomorphological study of malformed ossicles in the mousefetus caused by maternal hypervitaminosis A

Kajihara, Masayuki
96_585.pdf 4.71 MB
Published Date
1984-04-30
Abstract
Pregnant ddN mice were injected with 15,000 I.U. of water miscible vitamin A intraperitoneally on day 8 of pregnancy. Fetuses were removed surgically on day 18. Twenty of them were selected randomly to be sectioned horizontally and stained with hematoxylin and eosin solution for histological observation of the malformed ossicles. The malleus, incus and stapes were suggested by the observations to have developed directly from branchial arch cartilage: the former two from Meckel's cartilage and the latter from Reichert's cartilage. That the stapes was isolated might lend support to the theory of dual origin of the footplate. The above results were discussed with embryological and bibliographical considerations.
Keywords
hypervitaminosis A (ビタミンA過剰投与)
mouse fetus (マウス胎仔)
malformed ossicles (耳小骨奇形)
ISSN
0030-1558
NCID
AN00032489