Changes in hematologic parameters of dog due to exposure to trichloroethylene and 1,1,1-trichloroethane

Dogs were exposed to either trichloroethylene(TCL) or 1,1,1-trichloroethane(TCE) in order to investigate the effects of these solvents on hematologic parameters. Further-more, because of unusual changes in white blood cell counts following exposure of pregnant dogs to these solvents, investigation of the effects of several hormones given prior to exposure to the solvents was pursued. The results obtained were as follows. 1. White blood cell counts showed a marked decrease immediately after starting exposure to TCL or 1,1,1-TCE, though the decrease was temporary. On the other hand red blood cell counts, hematocrit values and blood platelet counts showed no changes. 2. While each kind of white blood cell decreased in number, the degree was greatest in neutrophils. 3. TCL caused a greater decrease in white blood cell counts than 1,1,1-TCE. 4. A dose-response relationship was seen between the concentrations of 1,1,1-TCE from 200 to 700 ppm and the decrease in white blood cell counts. 5. No change in white blood cell counts was observed following the exposure of pregnant dogs to 1,1,1-TCE. 6. Premeditation with estradiol, progesterone and hydrocortisone had a preventive effect on the decrease in white blood cell counts caused by the exposure to 1,1,1-TCE, but no such effect was seen with premedication of testosterone.