Urinary trichloroethanol and trichloroacetic acid excretion in workers exposed to various concentration of trlchloroethylene in an automobile parts factory (Part 1. Studies on trichloroethylene poisoning)

In order to know the relationship between concentration of trichloroethylne and the amount of urinary trichloroethanol or trichloroacetic acid, average concentration of trichloroethylene inhaled by the workers in an automobile parts factory was measured by Kitagawa detector tube at 20-minute's interval. And urinary trichloroethanol and trichloroacetic acid were determined by Ikeda's oxidation method of chromium trioxide and our direct colorimetric method. The results were as follows. 1. Straight relationship between trichloroethylene concentration in the air and trichloroethanol or trichloroacetic acid in the urine was recognized by Ikeda's method. 2. Urinary trichloroethanol and trichloroacetic acid concentrations in workers exposed to trichloroethylene were determined by both our direct colorimetric method and Ikeda's oxidation method of chromium trioxide. Correlation between urinary trichloroethanol and trichloroacetic acid determined by Ikeda's method and our direct colorimetric method was observed. 泄されるのであろうと言つている.1946年,Forssman,Ahlmark(2)3))はトリクレン蒸気中で働く労働者の訴えと,その尿中三塩化酢酸濃度との関係を見い出し,その75mg/lがトリクレン中毒の警戒すべき限界であると報告した.これに対して,1950年,Frant,Westeadorp(4))は,環境に気中のトリクレン濃度100ppmのもとで働く場合,その尿中には200mg/l濃度の三塩化酢酸を含むと述べられている.現在までは,三塩化酢酸の許容濃度はFrantの成績より75mg/lであるとしている.又,トリクレンの尿中代謝産物には三塩化エタノールのグルクロン酸抱合物もあり,soucek and Vlachova(5))等は1964年に,三塩化エタノールは,三塩化酢酸より排泄量が多く,しかも,排泄速度がはやい事を報告している.著者は実際の作業場で,三塩化エタノール,三塩化酢酸の関係を調べ,気中濃度との関係を求めた.又,三酸化エタノールの定量を池田氏の方法に比べて,簡便な定量を見いだした.そして作業者の尿を用いて,著者等の方法と池田氏の方法との相関を調べた.その成績をここに報告する.