Studies on Cross Neutralization Tests of Viruses from Lymphocytic Leukemia and Myelogenous Leukemia Derived during Serial Virus Inoculation Part 3 Cross Neutralization Tests of AKR Mouse Leukemia Viruses with Antiserum against C58 Mouse Leukemia Viruses

In the second report, by the method of cross neutralization tests, the author investigated seroimmunologically the possible correlation between the viruses of the original lymphocytic leukemia and the changed myelogenous leukemia in both strains of mice. In this experiment, with the purpose of further clarifying the immunological correlation among four viruses, the author performed cross neutralization tests of AKR mouse leukemia viruses with antiserum against C58 mouse leukemia viruses. As a result, cross neusralization between the viruses from C58 and AKR mice did not occur and the leukemia viruses from these two strains were shown immunologically to be considerably different. From all these facts reported in the present series of papers and other immunological experiments in our department, a change of the leukemia type was considered to be due to the difference in the tissue affinity of these two different viruses originally co-existed.