Steroid Metabolism in Walker Carcinoma Bearing Rat Part Ⅰ. On Steroid Meatbolism In Vivo

The cholesterol metabolism in male Wistar strain rat was studied on the biosynthesis of steroid hormone. 3H-cholesteryl ester was completely formed by 5 hours after the 3H-cholesterol administration from tail vein, and were recoginzed the metabolites from 3H-cholesterol in the adrenals, liver and serum after 2 hours. The steroid hormones from 3H-cholesterol observed maximum conversion at 5 hours. The metabolic processes were studied in rat bearing Walker carcinoma. The cholesterol conversion to steroid hormone in vivo in tumor bearing rat was elevated twice than the normal.