Experimental Studies on Hypersplenism Part 2 Experimental Splenic Anemia by Ligating Splenic Veins and Coronary Veins of the Stomach

After ligating splenic and coronary veins of the Stomach in normal rabbits, the author studied the blood and bone marrow pictures and iron metaborism, and obtained the following results. 1) In the peripral blood picture a transient little decrease in the erythrocyte count, hemoglobin content and platelet count could be observed. 2) In the bone marrow picture an increase and inhibition of mataration in the erythroid system could be observed. 3) Serum iron decreased conspicuously. However, the depot iron increased a little. 4) In the bone marrow picture a decrease of Sideroblast could be observed. 5) In the serum and spleen extracts, the existence of anemia producing toxic factor could be recognized. 6) From these observation, the author concluded that the principal cause of this anemia produced by the abdominal sympathectomy of splenic branches lay in the inhibition of maturation of the erythroblast as result of the inhibitory action of the toxic factor on the mobilization of depot iron.