Studies on Drin Intoxication 1. Toxicity of Drin compounds

Toxicity of drin compounds currently on market was investigated and the following results were obtained. 1. Endrin. The dose of LD50 was 5.2 mg/kg for mice and 13,7 mg/kg for rabbits when given subcutaneously, 6,6 mg/kg for mice and 5.2 mg/kg for rabbits when orally, and 54.8 mg/kg rats when given percutaneously. 2. Aldrin. The dose of LD50 was 49.2 mg/kg for mice and 56.6 mg/kg for rabbits when given subcutaneously, 64.8 mg/kg for mice and 36.7 mg/kg for rabbits when given orally, and 141.4 mg/kg for rats when given percutaneously. 3. Dieldrin. The dose of LD50 was 68.0 mg/kg for mice and 59.6 mg/kg for rabbits when given subcutaneously, 44.4 mg/kg for mice and 37.1 mg/kg for rabbits when given orally, and 186,6 mg/kg for rats when given percutaneously. 4. Toxic symptoms observed were episodic generalized seizure, salivation, restlessness, inactivity, loss of appetite, irritability, epiphora, fever, tachycardia, paralysis of four limbs, dyspnea, and cyanosis,