Experimental Studies on Effects of Parabiosis Formation on the Brain Metabolism of ep-Mouse Part Ⅲ Effects of Parabiosis on Glutamic Acid, γ-Aminobutyric Acid (GABA) and Aspartic Acid Content in the Brain of ep-Mouse

Biochemical changes as to amino acid metabolism were investigated in the brain of an ep-mouse, having had convulsive seizures, after parabiosis formation with a CF(1)-mouse, one of the normal other species, and the results of this experimeot were as follows: 1. Glutamic acid content was small in the brain of the ep-mouse compared with the CF(1)-mouse. They were approaching between the two levels 6 days after the procedure. Then, they were decreased below the preparabiosis level, showing insignificant defference between the both contents at the 12 th postparabiosis day. 2. GABA content was large in the brain of the ep-mouse compared with the CF(1)-mouse, but both contents were averaged between the levels 6 days after the procedure. They were recovered to the preparabiosis level of the CF(1)-mouse at the 12 th postparabiosis day. 3. Aspartic acid content was slightly large in the brain of the ep-mouse compared with the CF(1)-mouse. The difference was minimized after the procedure, and recovered to the preparabiosis level of the CF(1)-mouse at the 12 th postparabiosis day as in the case of GABA content.