Pathophysiological Study of the ep-Mouse Part Ⅱ Electroencephalogram of the ep-Mouse and Anticonvulsive Agents

An attempt was made to find out the effect of anticonvulsive agents such as diphenylhydantoin, phenobarbital and homocarnosine (γ-aminobutyryl-L-histidine) on the abnormal resting potentials of the ep-mouse. 1. Bilateral and sporadic spikes were noted to be characteristic abnormal potentials in the resting E. E. G. of the ep-mouse comparing with the one of the control, the CF-1 group. It was observed in 95% of the ep-mouse. 2. The spikes were found to be inhibited by the administration of phenobarbital: the absolute abolishment was obtained with 12 day successive administration of the 50～60mg/kg/day. 3. Such inhibition was also obtained by the administration of diphenylhydantoin: the absolute abolishment was obtained with 15 day successive administration of the 120～130mg/kg/day. 4. So was found in case of homocarnosine intracerebrospinal administration. The absolute abolishment of the spikes was found after the 7th post-administration day includingly. 5. The abolishment of the abnormal spike potential by these anticonvulsive agents was preceded by inhibition of convulsion.