Pathophysiological Study of the ep-Mouse Part Ⅰ Homocarnosine (r-Aminobutyryl-L-histidine) Effect on the ep-Mouse

Homocarnosine, one of the GABA associates was administered on the ep-mouse into cerebrospinal fluid through frontal region of intact scalp and skull. 1. Increased respiration and heart-beat and behavioral inhibition were observed in all cases immediately after the administration. Slight loss of body weight was followed for the first week in a half of the cases. 2. Anticonvulsive effect was obtained with the administration of homocarnosine. It is to be noted that the minimum effective dosage was 4-5 mg/kg which appears to be almost the same dosage contained in the cerebrum. 3. The anticonvulsive effect tended to be gradually accelerated by the time passing and to show the peak at the 3rd post-administration day, which was hardly varied during the following 2 month observation period. 4. Several associates of homocarnosine were examined in standpoint of anticonvulsive effect. Carnosine has also anticonvulsive effect, but less than homocarnosine. GABA, GABOB, histidine and alanine do not have such effect. 5. Homocarnosine does not cause any effect on acetylcholine and cholinesterase activity in cerebrum.