Amino Acid Metabolism of the Brain Part 1. Influences of Various Conditions on the Contents of Glutamic Acid and γ-Aminobutyric Acid in the Brain

The amount of glutamic acid and γ-aminobutyric acid in rabbit brain and human cerebral cortex under various conditions were determined by paperchromatography. The results were as follows: 1) After convulsion caused by electro-shock, the contents of glutamic acid and γ-aminobutyric acid in the rabbit brain markedly decreased. 2) In rabbits with repeated convulsions caused by electroshocks for 10 days (5 times every day), the contents of glutamic acid and γ-aminobutyric acid showed a decrease. 3) After the injection of chlorpromazin (50 mg/kg per time), the contents of glutamic acid and γ-aminobutyric acid decreased. 4) The contents of glutamic acid and γ-aminobutyric acid in the cerebral cortex of epilepsia were less as compared with non-epileptic patients (patients with brain tumor).