The Influence of Amino Acid upon Cholinestrase Activity in the Brain Part 1. The influence of amino acid upon cholinesterase activity in cerebral cortex of idiopathic epileptics

The ChE activity of cerebral cortex resected from idiopathic epileptics and non-epilcptics and the influences of glutamic acid, glutamine, aspartic acid, asparagine, γ-aminobutyric acid and γ-amino-β-hydrooxybutyric acid were studied. 1) In the brain of idiopathic epileptics, ChE activity is more markedly accelerated than that in the brain of non-epileptics. 2) By adding the amino-acids mentioned above, restraint occurs in each case. The intensity of these restraint for the non-epilcptic brain has the order of asparagine, glutamine, γ-amino-β-hydroxybutyric acid, glutamic acid, aspartic acid, glutamine. γ-aminobutyric acid, while that for idiopathic epileptic brain it is asparagine, aspartic acid, glutamine, γ-amino-β-hydroxybutyric acid, glutamic acid γ-aminobutyric acid. 3) The reduction of ChE activity by adding amino acids is found in each case of epileptic and non-epileptic brain. But it is not so definite in epileptic brain as in none-epileptic brain. 4) The ascending of ChE activity in idiopathic epileptic brain is regarded to be caused by the reduction of free amino acids in idiopathic brain.