Experimental Studies on Influence of Autonomic Nerve Effective Agents, Hormones and Electrical Stimulation of Hypothalamus upon Brain Edema Part I Influence of autonomic nerve effective agents upon brain edema

1) Autonomic nerve effective agents, i. e. adrenalin, atropine, acetylcholine and chlorpromazine were intramuscularly injected in three groups of cats; the normal, and one before and one after the experiment of producing brain edema. Their influences upon brain edema were investigated from the point of water content in cerebral cortex by Hatschek's cobalt chloride method. 2) Bilateral jugular veins were ligated for producing brain edema. 3) In normal cats, these agents had no influence. 4) In the group injected before producing brain edema, chlorpromazine markedly depressed the progress of the brain edema, while adrenalin, atropine or acetyl-choline gave almost no influence. 5) In the group injected after producing brain edema, chlorpromazine also showed depressive effects to the progress of the brain edema, while adrenalin accelerated it. But acetylchloine and atropine gave no influence. 6) The change of water content mainly consisted in free water and total water. Bound water remained almost unchanged.