The Influences of Various Hormones on the Function of Megakaryocytes By Means of Bone-Marrow Tissue Culture Part 2. Influences of Various Sex Hormones on the Function of Megakaryocytes

By means of bone-marrow tissue culture the author studied the influences of various sex hormones on the function of megakaryocytes, and obtained the following results: 1. The male sex gland and the megakaryocyte function: By repeated administration of testosterone to normal guinea pigs the megakaryocyte function is accelerated, while the megakaryocyte function is diminished in the guinea pigs devoid of testicles. Furthermore, when testosterone is added directly to the bone-marrow tissue culture of normal person the megakaryocyte function is accelerated. 2. The female sex gland and the megakaryocyte function: In the repeated administration of estradiol to normal guinea pigs, the megakaryocyte function is diminished, whereas the removal of guinea-pig ovaries by operation accelerates the megakaryocyte function. Moreover, the direct addition of estradiol to the bone-marrow tissue culture of normal person decreases the mcgakaryocyte function. On the other hand, repeated administration of progesterone to normal guinea pigs increases the megakaryocyte function. In addition, when progesterone is added directly to the bone-marrow tissue culture of normal person, the megakaryocyte function is accelerated.