Polarographic Studies on Proteins of the Cerebrospinal Fluid Part 1. Studies on General Characteristics of the Cerebrospinal Fluid Wave and the Same in Schizophrenics

The author carried out polarographical studies on proteins of the cerebrospinal fluid, and also investigated general characteristics of the wave of the cerebrospinal fluid proteins by the routine polarography, using the cerebrospinal fluid of schizophrenic patients as the material. The results are as follows: 1. Tropp's crossing point proved to be 10.0 mg% in the primary reaction while it was 3.7 mg% in the secondary reaction. 2. As for the polarogram of the cerebrospinal fluid of schizophrenia, the primary reaction clearly shows a two-step wave, being always H(2) > H(1). In the secondary reaction the wave form approaches close to the single wave, but still it is H(2) > H(1). By the urea denaturation both H(1) and H(2) somewhat decrease in the primary reaction, whereas both increase slightly in the secondary reaction. 3. It has been clarified that the substances involved in the primary and secondary reactions in the cerebrospinal fluid are different from the similar substances in the serum.