Studies on the TCA Cycle in the Brain Mitochondria. 1. On the Normal Rabbit Brain and the rabbit Brain with Latent Cerebral Local Anaphylaxis

1. The respiration of mitochondria was measured by the Warburg's manometer and the intermediates of the TCA cycle were used as the substrates. 2. The O(2)-uptake of the normal rabbit brain mitchondria is about twice of the rabbit mitochondria with latent cerebral local anaphylaxis. 3. On the stimulation of the substrate; The succinate, α-ketoglutarate, oxalacetate and pyruvate accelerate the O(2)-uptake in both cases, but the O(2)-uptake of the normal brain is always more than that with anaphylaxis. 4. Fumarate stimulates the O(2)-uptake of the normal brain, but does not stimulate that with anaphylaxis. 5. Citrate and malate do not accelerate in both cases.